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09.06.2020 |

CRISPR-edited rice shows wide range of unintended mutations

Gene-editing tool "not as precise as expected", say researchers in new study. Report: Claire Robinson

CRISPR gene editing in rice varieties caused a wide range of undesirable and unintended on-target and off-target mutations, according to an important new study authored by a Chinese and Australian team of scientists and published in the Journal of Genetics and Genomics.[1]

The researchers were trying to improve the yield of already high-performing varieties of rice by disrupting the function of a "green revolution" semi-dwarfing gene (SD1). They used a stable transformation method that ensured that the CRISPR editing tool remained active in the plants over four generations, so that they could examine the effects over time.

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