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10.02.2022 |

CRISPR/Cas in animals: Unintended changes and unexpected patterns of inheritance

Findings relevant for planned marketing of GE laying hens

10 February 2022 / In experiments with zebrafish, researchers have for the first time shown that unintended effects of CRISPR/Cas applications are inherited in subsequent generations. They also found unusual patterns of inheritance. According to the scientists, the findings show that the effects of CRISPR/Cas applications on subsequent generations need to be examined in much greater detail.

Previous experiments with CRISPR/Cas in zebrafish have found large structural changes at off-target sites. This means that the gene scissors can cut genomic regions outside of the target site, and thus cause specific unintended mutations. The experiments are part of basic research. In this context, zebrafish are seen as important model organisms. The researchers assume that unintended genetic changes at off-target sites can be more concerning compared to those at on-target regions, as the effects may go unnoticed.

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